If you have a lot of experience, are well trained, and are a "type" that they are interested in at the time, they will call. In the large markets such as Los Angeles and New York, it can be extremely difficult for even experienced and well trained actors to land an agent, so keep your expectations realistic when submitting, and be patient. Try again in a few months if they do not call. If you are doing a play or showcase, send a postcard to invite an agent to come see you perform.
Also, don't expect to be able to pick and choose an agent unless you are a very well known and respected actor. I see so many people asking, "What is the best agent in LA (or NY or wherever)?" If you have to ask that question, you certainly are not an actor who can "pick and choose" an agent. 99% of actors should consider themselves lucky to sign with a SAG-AFTRA franchised or ATA/NATR Agency. You can send a photo and resume to every legit talent agent in LA or NY and would be lucky to get one single call.
And one last thing..... just because an Agency is a "licensed Talent Agent" in your state does NOT mean that they are a good or even legit agent. The rules to become a licensed Talent Agent in every state are MUCH more lenient than the rules to become a SAG franchised agent or ATA/NATR agent. I would only recommend signing with an agent that is franchised with the Screen Actors Guild, or a member of the Association of Talent Agents (ATA) or National Association of Talent Representatives (NATR).